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Neglected zoonotic diseases (NZD) in developing countries

In developing countries, there are a number of endemic zoonoses which have been eradicated in developed countries, and these diseases have huge impacts on the economics and public health. However limited domestic and international resources are heavily allocated to trans-boundary zoonoses such as avian influenza, and other specific lethal diseases such as HIV/AIDS and tuberculosis. Therefore there is a list of diseases called as ‘Neglected zoonotic diseases’ by the WHO.

Dr. Makita has been researching on brucellosis, which is a NZD, in Uganda since 2005. Brucellosis is one of the most prevalent zoonoses in the world and it causes abortion to livestock and systematic illness such as continuous and undulant fever and fatigue as well as localized lesions such as arthritis to humans. The Veterinary Epidemiology unit is going to research in Vietnam and Tanzania to identify sustainable disease control together with communities.

Research funding

2017-2018‘Control of rabies in the endemic area based on One Health approach.’ Rakuno Gakuen University Collaborative Research Grant. PI
2016-2018‘Effective infectious disease control using quantitative epidemiology and economics.’ MEXT, Japan, Private university development of research platform grant. Co-PI.
2013-2015Japan Intellectual Support Network in Agricultural Sciences (JISNAS).
2013-2016Ministry of Education, Culture, Sports, Science and Technology, Science Research Grant B, as a collaborator of Dr. Kono, Obihiro University of Agriculture and Veterinary Medicine.
2005-2008UK Department for International Development (DFID) Animal Health Programme (PhD in University of Edinburgh).

Performance

Peer review paper

Kothalawala KAC, Makita K, Kothalawala H, Jiffrey AM, Kubota S, Kono H. 2017. Association of farmers' socio-economics with bovine brucellosis epidemiology in the dry zone of Sri Lanka. Preventive Veterinary Medicine 147: 117-123.

Makita K, Fèvre EM, Waiswa C, Kaboyo W, Eisler MC, Welburn SC. (2011) Evidence-based
identification of the most important livestock related zoonotic diseases in Kampala, Uganda, J Vet
Med Sci, 73, 991-1000.

Makita K, Fèvre EM, Waiswa C, Eisler MC, Thrusfield M, Welburn SC. (2011) Herd prevalence of
bovine brucellosis and analysis of risk factors in cattle in urban and peri-urban areas of the Kampala
economic zone, Uganda, BMC Vet Res, 7, 60.

Makita K, Fèvre EM, Waiswa C, Kaboyo W, Eisler MC, Welburn SC. (2011) Spatial epidemiology
of hospital-diagnosed brucellosis in Kampala, Uganda, Int J Health Geographics, 10, 52.

Makita K, Fèvre EM, Waiswa C, Eisler MC, Welburn SC. (2010) How human brucellosis incidence
in urban Kampala can be reduced most efficiently? A risk assessment of informally marketed milk,
PLoS ONE, 5, e14188.

Makita K, Fèvre EM, Waiswa C, Kaboyo W, Bronsvoort MDC, Eisler MC, Welburn SC. (2008)
Human brucellosis in urban and peri-urban areas in Kampala, Uganda, Ann N Y Acad Sci, 1149,
309-311.



Invited presentations

Makita K. What is One Health? One World One Health research forum. 2017 July 9, Hokkaido University, Sapporo, Japan.

Kadowaki H, Makita K, Phuc PD, et al. Preliminary report: Socio-economic study for rabies in Thai Nguyen Province, Vietnam. 2017 February 14, Thai Nguyen, Vietnam.

Makita K. Incentive-based improvement of food safety and zoonosis risks in sub-Saharan Africa. Japanese – Swiss EcoHealth Colloquium. JSPS. 2017 January 10-12, Swiss TPH, Basel, Switzerland.

Makita K. International collaborative researches in Rakuno Gakuen University OIE Centre. Invited speech. Symposium ‘Young researchers challenging infectious disease control’, Nihon University, 2016 December 2, Kanagawa, Japan.

Makita K. (2015) Epidemiology for strategic control of Neglected Zoonoses. At FAO-APHCA/OIE/USDA Regional Workshop on Prevention and Control of Neglected Zoonoses in Asia. 2015 July 15-16, Obihiro, Japan.

Invited as an expert of veterinary epidemiology and socio-economics, WHO/OIE/FAO Asia-Pacific
Workshop on Multisectoral Collaboration for Zoonoses Prevention and Control. 27-29 November
2013, Kathmandu, Nepal (2013).



Presentations at international conferences

Kadowaki H, Makita K, Hampson K, Yamada A. Quantitative risk assessment of dog rabies spreading Japan using mathematical modelling. Japan-Republic of Korea Joint Symposium on Veterinary Epidemiology, 2016 June 11, University of Tokyo, Tokyo, Japan.

Makita K. Elimination of rabies – lessons from pre and post vaccination era in Osaka, Japan. RGU OIE Seminar ‘Control of endemic zoonosis’, 2016 September 19, Sokoine University of Agriculture, Tanzania.

Asakura S, Makingi G, Kazwala R, Makita K. Prevalence of bovine brucellosis and its risk factors in Morogoro Region, Tanzania. One Health EcoHealth 2016. The 4th International One Health Congress and 6th Biennial Congress of the International Association of Ecology and Health, 2016 December 3-7, Melbourne, Australia.

Makita K, Fèvre EM, Waiswa C, Eisler MC, Welburn SC: Risk analysis for purchase of milk
infected with Brucella abortus in urban areas of Kampala, Uganda, The 12th International Symposium on Veterinary Epidemiology and Economics, (2009).



Presentations at conferences in Japan

Asakura S, Makingi G, Kazwala G, Makita K. 2017. Quantitative analysis for the risk factor of bovine brucellosis and willingness to control in agro-pastoral area in Tanzania. Japan Society of Veterinary Medical Science, 2017 September 13-15, Kagoshima University.

Asakura S, Makingi G, Kazwala R, Makita K. 2016. Prevalence and associated risk factors of bovine brucellosis in Morogoro Region, Tanzania. Japan Society for Veterinary Epidemiology, 2016 March 20, University of Tokyo, Tokyo, Japan.

Kadowaki H, Makita K, Hampson K, Yamada A. 2016. Economic analysis of rabies control measures once rabies is introduced to Japan. Japan Society for Veterinary Epidemiology, 2016 March 20, University of Tokyo, Tokyo, Japan.

蒔田浩平, Fèvre EM, Waiswa C, Eisler MC, Welburn SC: ウガンダ国首都カンパラの都市部に
おける、非正規流通牛乳の摂取によるヒトブルセラ病感染リスク評価およびリスク低減シ
ミュレーション. 獣医学会 (2010).

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