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Antimicrobial resistance

Antibiotics have been contributing greatly to protecting our health, and even that of food animals when they are sick. However, the use of antibiotics may select antimicrobial resistance in animals.

The Veterinary Epidemiology Unit is analyzing the association between the use of antibiotics at farm level and the selection of antimicrobial resistance in the bacteria of animal origin, and also is assessing the risks to humans.

Research funding

2017-2018‘Prevalence of colistin resistant bacteria and analysis of characteristics’ Food Safety Commission Food safety risk assessment. Co-PI.
2017-2018Collaborative Research with the Ministry of Agriculture, Forestry and Fisheries National Veterinary Assay Laboratory. PI.
2013-2014Establishment of quantitative risk assessment model for fluoro-quinolone resistant Campylobacter of poultry origin. Japan Food Safety Commission, 2013-2014. Co-PI.
2012-2015Collaborative Research with National Veterinary Assay Laboratory, Japan


Peer review paper

Makita K., Goto M., Ozawa M., Kawanishi M., Koike R., Asai T., Tamura Y. (2015) Multivariable analysis of the association between antimicrobial use and antimicrobial resistance in Escherichia coli isolated from apparently healthy pigs in Japan. Microbial Drug Resistance [electronically published ahead of print].

Usui M, Ozawa S, Onozato H, Kuge R, Obata Y, Uemae T, Ngoc PT, Heriyanto A, Chalemchaikit T, Makita K, Muramatsu Y, Tamura Y. (2014) Antimicrobial susceptibility of indicator bacteria isolated from chickens in Southeast Asian countries (Vietnam, Indonesia, and Thailand). Journal of Veterinary Medical Science (electronically published ahead of print).

Ozawa M, Makita K, Tamura Y, Asai T. (2012) Associations of antimicrobial use with antimicrobial
resistance in Campylobacter coli from grow-finish pigs in Japan, Prev Vet Med, 106 (3-4), 295-300.

Ishihara K, Takahashi R, Andoh M, Makita K, Kamiji S, Ueno H, Muramatsu Y, Tamura Y. (2011)
Effects of climatic elements on Campylobacter-contaminated chicken products in Japan, Epidemiol
Infect, 12, 1-6.

Ishihara K, Hosokawa Y, Makita K, Noda J, Muramatsu Y, Ueno H, Mukai T, Yamamoto H, Ito M,
Tamura Y. (2011) Factors associated with antimicrobial-resistant Escherichia coli in zoo animals,
Res Vet Sci, 93(2), 574-80.

Invited presentations

Makita K. 2017. Sampling strategy and multivariable analysis in the AMR monitoring. NVAL-UoT-RGU-VPHC joint OIE Seminar, 2017 October 19, University of Tokyo.

Presentation at international conferences

Toyofuku H., Makita K., Osada Y., Ohashi T., Kakinuma M., Ooshiki D. (2015) A stochastic assessment of the public health risks of the use of fluoroquinolones in broiler in Japan. International Society for Veterinary Epidemiology and Economics (ISVEE 14) conference.

Presentations at conferences in Japan

Ozawa M, Makita K. 2017. Mechanism of co-selection in Escherichia coli. Japan Society of Veterinary Medical Science. 2017 September 8. Kagoshima University.

Goto M, Makita K, Ozawa M, Asai T, Tamura Y. (2013) Association between use of antimicrobials and antimicrobial resistance in Escherichia coli of health pig origin in Japan. Conference of Japan Society of Veterinary Medicine.

後藤聖樹,蒔田浩平,小澤真名緒,浅井鉄夫,田村豊:我が国の養豚場における抗菌性物質の使用と薬剤耐性大腸菌の分布との関係,獣医疫学学術集会 (2011).

Rakuno Gakuen University Veterinary Epidemiology(2014.05.16)|